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If the Marvel super heroes knew all they had to do to defeat all kinds of villains was to beat them at match-3, they'd probably be a lot less angst-ridden. To date, no comic book writer has actually decided to act on this idea, but Marvel Puzzle Quest: Dark Reign comes close. Taking the core gameplay from , Marvel Puzzle Quest takes place after The Pulse, which sounds like something from Dimension Films but is actually a mysterious event that introduced the world to Isotope-8 (or just ISO-8, for short). The new element can make super-powered folks even stronger, and is thus coveted pretty highly by the forces of evil.

Though you only get a cursory introduction to all of this if you haven't played the other games, S.H.I.E.L.D. has been keeping tabs on ISO-8. The new twist here is that Norman Osborn, the artist formerly known as the Green Goblin, has wormed his way into a position of power, and his H.A.M.M.E.R. organization has booted Nick Fury and company out of favor with the world's governments. This can all be a little overwhelming if you aren't versed in the source material, which might be the game's most glaring weakness.